The AD8—Dementia Screen Ready for Prime Time?
questionnaire to probe cognitive function, and was whittled down to a final eight items (Galvin et al., 2005).
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Untapped Resource? New Study to Boost Acceptance of CSF Analysis
mild cognitive impairment to AD (see Hansson et al., 2006; Fagan et al., 2006; Shaw et al., 2009; and
Microdissection and Microarrays: Analyzing Selective Cell Vulnerability
Sweden, recently reported on selective cell vulnerability in motor neuron diseases (Hedlund et al., 2010).
Together at Last, Top Five Biomarkers Model Stages of AD
Neurology (Jack et al., 2010). Jack’s coauthors include clinicians David Knopman and Ron Petersen at Mayo;
Treating Before Symptoms—ADCS Invites Ideas for Clinical Trials in Very Early AD
Petersen criteria for amnestic MCI (Petersen et al., 1999; Petersen, 2004), though the memory impairment
Collective Thought at Its Best: Let’s Contemplate the Centennial
One hundred years ago, in January of 1907, Alois Alzheimer published his landmark paper about Auguste D. This is a perfect time to sit back and contemplate the field’s past accomplishments and future challenges. The Alzforum editors have compiled some mat
Seeded Aggregation and Transmissible Proteopathy—Creepy Stuff Not Just for Prions Anymore?
can also cause disease characteristics or phenotypes (Collinge et al., 2007). But are prions truly
Betwixt and Intermixed—Dementia With Lewy Bodies
On 15 June 2009, we hosted a Webinar discussion with slide presentations by Ian McKeith at Newcastle University, UK, James Leverenz at University of Washington, Seattle, James Galvin, Washington University, St. Louis, Brit Mollenhauer of Paracelsus-Elena
Can We (Should We?) Develop “Smart Drugs” to Stave Off Age-Related Memory Loss?
al., 2002; Grön et al., 2005; Chuah and Chee, 2008; FitzGerald et al., 2008). The Alzforum set out to
LOAD and eFAD—Different Diseases, Different Hypotheses?
flow. (Editor’s note: see recent paper about connectivity data in young ApoE4 data: Filippini et al.,
Meet New Players, Histone Deacetylase and Sirtuin—Will They Help the Cell Cycle, DNA Repair, and Gene Expression Break Into Alzheimerology’s Major League?
important roles of protein acetylation. I am also referring to this month’s paper by Creppe et al., 2009 on
Calcium in AD Pathogenesis
for "amyloid attack" (based on Harvey Pollard’s and Arispe's work; see Lee et al.,
The Pathogen Hypothesis
associated mental impairment in mice (see Aleksandrova et al., 2004). Thus the need for many more controls to
Leon Thal Symposium Webinar
On Monday, 27 October 2008, a live Webinar was held by Alzheimer’s research leaders on a national action plan to accelerate discoveries of treatments to prevent dementia. The plan will be presented to the 111th U.S. Congress in March 2009. Presentations w
Early Detection of Alzheimer Disease—A Virtual Town Hall Meeting
health issue, and if so, is there a national plan to address it (Brookmeyer et al., 1998)? Q: For Drs.
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.
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